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NEWS: Deselection of Physiologically Abnormal Spermatozoa Before ICSI Reduces Birth Defects and Improves Clinical Results

Sperm morphology plays a vital role in determining fertility and is associated with fertilization and pregnancy rates in spontaneous as well as induced pregnancy. Highlighting the importance of the selection of morphologically normal spermatozoa for ART treatment, a recent prospective population-based study demonstrated that major birth defects were significantly higher in standard ICSI than intracytoplasmic injection of morphologically selected spermatozoa (IMSI). The study findings, published in Reproductive BioMedicine Online, further reiterated the need for long term follow up and research to estimate the prevalence and risk of specific IMSI-based birth defects.
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Posted in ART, Genetics, ICSI, IVF Outcome, Infertility, Male Infertility, Pregnancy, TechnologyComments Off

NEWS: IVF culture medium plays a crucial role in influencing intrauterine growth

It has been speculated that in vitro culture medium may significantly contribute to poor perinatal outcomes following assisted reproduction technology (ART) cycles. Now, a recent retrospective cohort study, published in the journal Human Reproduction, reports that the effect of the IVF culture medium on fetal development is obvious as early as the second trimester of gestation.
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NEWS: Presence of soluble HLA-G in embryo culture medium serves as a valuable marker of pregnancy outcomes

Previous trials have demonstrated a positive association between secretion of soluble human leukocyte antigen G (sHLA-G) by embryos and a higher rate of pregnancy in in vitro fertilization (IVF) cycles. Now, a recent multicenter retrospective trial provides evidence to substantiate that sHLA-G is a useful noninvasive embryo marker to aid in improving pregnancy outcomes.
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NEWS: Carnitine supplementation may benefit women undergoing IVF therapy

Fatty acids play a crucial role in energy supply to oocytes and embryos, and L-carnitine mediates the β-oxidation of free fatty acids. A recent case-control study, published in the journal Reproductive Biology and Endocrinology, demonstrates the benefits of evaluation of carnitine profiles in women undergoing in vitro fertilization (IVF) therapy.
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NEWS: Array CGH is effective for preimplantation genetic screening of blastocysts

Previous studies have validated array comparative genomic hybridization (aCGH) as an accurate method for comprehensively analyzing the chromosomal structure of day-3 and day-5 embryos in a fresh cycle. A recent study provides further evidence to substantiate that comprehensive chromosome analysis through aCGH is effective for preimplantation genetic screening (PGS) of blastocysts in in vitro fertilization (IVF) therapy.
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NEWS: Reducing intrauterine MMP activity may facilitate successful implantation in RIF patients

Chronic uterine inflammation, one of the factors implicated in repeated implantation failure (RIF), is associated with high intrauterine matrix metalloproteinase (MMP) activity. Significantly higher intrauterine MMP activity has been reported in infertile women with RIF compared to their fertile counterparts. A recent retrospective study reports that a two-week course of antibiotics and corticosteroids reduces MMP activity and improves the uterine environment, facilitating successful implantation in such patients.
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NEWS: A novel closed vitrification device reported to be effective to vitrify cleavage and blastocyst stage embryos

Open vitrification devices for embryo cryopreservation allow direct contact between embryo samples and liquid nitrogen, posing a risk of infection or cross-contamination between specimens. The advent of closed vitrification devices has circumvented these risks associated with open vitrification devices. A recent study highlights that Rapid-iTM, a new closed vitrification device, serves as an excellent alternative to the current open vitrification devices to cryopreserve embryos at the cleavage as well as the blastocyst stage.
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Posted in Cryopreservation, Equipments, Laboratory, NewsComments Off

NEWS: Brief co-incubation insemination protocol may enhance IVF outcomes

The standard overnight co-incubation of spermatozoa and oocytes has been compared with the brief co-incubation insemination protocol by numerous investigators in the past. However, it remains unclear whether reduction in the sperm-oocyte co-incubation time improves or negatively affects the outcomes of in vitro fertilization (IVF) therapy. According to a recent Cochrane review, the brief gamete co-incubation insemination protocol may improve the rates of ongoing as well as clinical pregnancy in infertile women undergoing IVF therapy.
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Advanced sperm selection techniques and their effects on ART outcome

ABSTRACT: Sperm selection in vitro has a direct impact on paternal contribution to preimplantation embryogenesis. Conventional sperm selection techniques are based on microscopic assessment of motility and morphology alone and do not include characteristics that influence the fertilization potential of spermatozoa. Chromosomal aberrations have been readily noted in sperms classified as normal via the Strict Kruger morphological assessment, questioning the value of using this parameter for sperm selection in intracytoplasmic sperm injection (ICSI) cycles. Furthermore, several studies have demonstrated that visual evaluation alone may inadvertently facilitate selection of sperms with compromised developmental, cytoplasmic, and nuclear competence. Hence, advanced techniques have been developed to address these issues in sperm selection. This review summarizes literature evidence on various advanced sperm selection techniques and their impact on assisted reproductive technology (ART) outcomes.
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Posted in ICSI, IVF Outcome, Laboratory, Male Infertility, Review ArticlesComments Off

NEWS: Presence of microorganisms in follicular fluid may negatively influence IVF outcomes

Microbial colonization of the female upper genital tract even in the absence of symptomatic infection has been well documented in previous trials. A recent study demonstrates that the presence of microbes in the follicular fluid collected at the time of transvaginal oocyte retrieval adversely affects the outcomes of in vitro fertilization (IVF) therapy.
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Posted in Female Infertility, IVF, IVF Outcome, Laboratory, NewsComments Off


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