Archive | Media and Consumables

Meta-analysis Reports Better IUI Pregnancy Rates with Recombinant FSH Compared to Same Dose of Highly Purified Urinary FSH

The in vitro production of pure FSH using recombinant DNA technology (rFSH) with high batch-to-batch consistency has led to it being considered as a better alternative to urinary FSH. A new systemic review and meta-analysis reports that use of rFSH is associated with an increased pregnancy rate (PR) per IUI cycle compared to the same dose of highly purified urinary FSH (HP-FSH). Interestingly, the PRs were comparable on using 50% reduced dose of rFSH. Continue Reading

Posted in ART, Drugs, Endocrinology, Female Infertility, Fertility, IUI, IVF, IVF Outcome, Infertility, Male Infertility, Media and Consumables, Technology0 Comments

NEWS: Polyanionic Microbicide for Sperm Washing Shown to Reduce HIV Transmission during ART

NEWS: Polyanionic Microbicide for Sperm Washing Shown to Reduce HIV Transmission during ART

Sperm washing alone may aid in reducing the risk of transmitting HIV infection to the partner and offspring; however, several studies have noted that HIV titers could still be significant in around 4-6% of washed sperm samples. A team of US researchers have reported the potential of an improved sperm washing method, which includes the use of a microbicide, polyanionic microbicide (PPCM), and extracellular Ca2+ in the washing media, in significantly lowering the HIV infectivity compared to traditional washing techniques. The study findings are published in the journal, ISRN Obstetrics and Gynecology. Continue Reading

Posted in ART, Drugs, Featured, ICSI, IUI, Infertility, Laboratory, Male Infertility, Media and Consumables, News, Pregnancy, TechnologyComments Off

NEWS: Determining Embryo’s Oxidative Status in Culture Media May Help Improve Implantation

Conventionally used measures to determine embryo quality, such as morphology and cleavage rate, have limited ability to predict successful outcome. A recent prospective laboratory study suggests that the evaluation of the oxidative status of an early embryo in the culture media may serve as a novel technique for improving embryo selection in IVF-ET cycles. The results of the study are published in the journal, Fertility and Sterility. Continue Reading

Posted in ART, Diagnostics, Embryology, Equipments, Female Infertility, Fertility, Fertility Preservation, IVF, IVF Outcome, Implantation, In-vitro Maturation, Infertility, Laboratory, Media and Consumables, News, Pregnancy, TechnologyComments Off

Study Reiterates Efficacy of Long-term Liquid Nitrogen Storage for Preserving Sperm Motility

Study Reiterates Efficacy of Long-term Liquid Nitrogen Storage for Preserving Sperm Motility

Sperm banking has been recognized as an effective strategy to circumvent iatrogenic infertility and also retain the reproductive potential of adolescent and young adult males undergoing cancer therapy. However, the effect of long-term cryopreservation on the fertilization potential of sperm has been contentious. Now, a study performed by a group of Israeli researchers rules out any negative influence of prolonged storage in liquid nitrogen on the progressive motility concentration (PMC) of sperm. The results are published in the online issue of the journal Human Reproduction. Continue Reading

Posted in Cryopreservation, Embryology, Equipments, Featured, Fertility, Fertility Preservation, Infertility, Laboratory, Male Infertility, Media and Consumables, TechnologyComments Off

Vapor-phase Nitrogen System Superior to Traditional Liquid Nitrogen for Storing Vitrified Human Oocytes

Any therapeutic intervention in reproductive biology must ensure complete protection of biological materials against a wide range of microorganisms. Liquid nitrogen (LN) used for cryostorage collects particulate contaminants from the atmosphere or container surface over a period of time, which could be a potential source of pathogenic microbes, including herpes, papova, hepatitis, and vesicular stomatitis virus. A new study suggests that storage of vitrified oocytes using the vapor-phase nitrogen systems serve as a safer alternative to the traditional LN storage tank, as it avoids the risk of cross-contamination, apart from retaining the developmental potential of these oocytes. The findings of the prospective randomized trial have been published in the latest issue of Fertility and Sterility. Continue Reading

Posted in ART, Cryopreservation, Embryology, Equipments, IVF Outcome, Infertility, Laboratory, Media and Consumables, News, TechnologyComments Off

ALERT: In Vitro Culture Medium Shown to Influence Birthweight of Singleton Newborns

Numerous studies have documented that the birth weight of IVF-conceived newborns is lower than those conceived naturally, possibly attributable to factors such as multiple gestations and various causes of female infertility. A new study reports that the type of culture medium used for in vitro culturing of the preimplantation embryos could also influence the birthweight of babies born through IVF. The findings of the study are published in the latest issue of the journal, Human Reproduction. Continue Reading

Posted in ART, Embryology, Female Infertility, Fertility, IVF, IVF Outcome, Infertility, Laboratory, Media and Consumables, Pregnancy, TechnologyComments Off

Culture Systems Mimicking In Vivo Biomechanical Environment may Enhance Embryonic Developmental Competence

Several factors related to embryo culturing, including the procedure and incubation time for both the gametes and embryos, are reported to significantly affect IVF treatment outcomes. Two Independent studies have reported the development of two novel embryo culture systems, namely the tilting embryo culture system (TECS) and the microfluidic/microfunnel system, to mimic the in utero conditions in order to augment the development of the embryo and formation of blastocyst. Continue Reading

Posted in ART, Embryology, IVF, IVF Outcome, Laboratory, Media and Consumables, TechnologyComments Off

Slow Freezing Superior to Vitrification in Preserving Ovarian Development and Proliferation Potential

Vitrification, compared to conventional or slow freezing, is an effective technique for cryopreserving oocytes and embryos; however, its comparative efficacy in ovarian tissue cryopreservation is not proven. Now, a study published in the recent issue of the journal Reproduction reports that conventional freezing is more effective in the cryopreservation of ovarian tissue, as it preserves greater developmental and proliferative potential. Continue Reading

Posted in ART, Cryopreservation, Female Infertility, Infertility, Media and Consumables, TechnologyComments Off

ALERT: Fertilization Rate is a Strong Predictor of Successful Implantation in Assisted Reproduction

Embryo implantation is predicted using various parameters such as follicle size, oocyte quality, endometrial thickness, and the estrogen levels on the day of hCG administration. Due to the multifactorial influence on successful implantation, a single independent predictor remains elusive. Now, a recent retrospective cohort study published online in Fertility and Sterility reports that the rate of fertilization is a robust independent predictor of successful implantation during ART. Continue Reading

Posted in ART, Female Infertility, ICSI, IVF, IVF Outcome, Infertility, Media and Consumables, News0 Comments

Sperm DNA Damage during Cryopreservation Attributed to Elevated Oxidative Stress

There exists ample evidence on the possibility of cryopreservation negatively affecting sperm DNA integrity; however, its precise underlying mechanism is still much debated. Now, a recent study published in the online issue of the journal Human Reproduction, reports that cryopreservation-induced injury to sperm DNA is mediated primarily through oxidative stress rather than apoptosis. Continue Reading

Posted in ART, Cryopreservation, Embryology, Genetics, Infertility, Laboratory, Male Infertility, Media and Consumables, Technology0 Comments



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