Archive | Male Infertility

New Study Reassures on the Use of Assisted Oocyte Activation in ICSI Cycles

A recent study reports that the behavioral and neurodevelopment outcomes are normal in children born after assisted oocyte activation (AOA) using calcium ionophore in ICSI cycles. Touted to be the first study assessing the developmental outcome of children born following AOA, the preliminary findings are published in Reproductive BioMedicine Online.
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New Prospective Cohort Study Reports the Association between Preconception Stress and Enhanced Infertility Risk

Literature evidence suggests a close inter-relationship between stress and reproduction, but its directionality is not clearly known. Recently, a US study demonstrated that increased stress levels in couples, as evaluated by salivary alpha-amylase, may lead to longer time-to-pregnancy (TTP) and a higher risk of infertility. The findings, touted to be the first in the world to prospectively link salivary stress markers with infertility, are published in the journal Human Reproduction.
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NEWS: Deselection of Physiologically Abnormal Spermatozoa Before ICSI Reduces Birth Defects and Improves Clinical Results

Sperm morphology plays a vital role in determining fertility and is associated with fertilization and pregnancy rates in spontaneous as well as induced pregnancy. Highlighting the importance of the selection of morphologically normal spermatozoa for ART treatment, a recent prospective population-based study demonstrated that major birth defects were significantly higher in standard ICSI than intracytoplasmic injection of morphologically selected spermatozoa (IMSI). The study findings, published in Reproductive BioMedicine Online, further reiterated the need for long term follow up and research to estimate the prevalence and risk of specific IMSI-based birth defects.
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NEWS: Study Reiterates the Association of Sperm Viral Infection like HCMV with Male Infertility

Viral infection of testicular cells may alter testicular function, posing severe risk to fertility and potential transmission of virus-induced mutations to future generations. A review, published in Journal of Reproductive Immunology, highlighted the negative impact of sperm viral infections with human cytomegalovirus (HCMV), human papilloma virus (HPV), and herpes viruses (HSV) on male reproductive function. The researchers emphasized the importance of screening male infertility patients for viral infections like HCMV to avert transmission to partners and newborns and also to enhance natural or assisted conception outcomes.
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New Study reports Effectiveness of Varicocelectomy in Improving ICSI outcomes

Studies have shown inconsistent results regarding the effect of varicocelectomy on fertility and ART outcome. A recent retrospective study, published in International Urology and Nephrology, reported the beneficial effects of varicocelectomy in improving pregnancy and live birth rates in infertile couples, wherein the male partner has clinical varicocele.
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NEWS: Benefits of in vitro treatment of spermatozoa with an antioxidant and micronutrient combination

Several studies have evaluated the beneficial effects of oral antioxidant administration on sperm physiology and fertility. However, data regarding the in vitro effects of antioxidants on spermatozoa is very sparse. Now, a recent study demonstrates the in vitro protective effect exerted by a combination of zinc (Zn), D-aspartate (D-Asp), and coenzyme Q10 (CoQ10) on sperm physiology parameters. Supplementation of culture medium with this antioxidant and micronutrient combination has been reported to prevent an increase in sperm DNA fragmentation and lipid peroxidation, and preclude a reduction in sperm motility.
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NEWS: Spermatid specific thioredoxin-3 protein may serve as a unique biomarker of male infertility

A recent study highlights that the semen levels of spermatid specific thioredoxin-3 (SPTRX3), a protein that cumulates in the superfluous cytoplasm of defective spermatozoa, may serve as a potential biomarker of male infertility. The study has demonstrated that high semen levels of SPTRX3 correlate with reduced pregnancy rates in couples undergoing assisted reproductive technology (ART) cycles.
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Advanced sperm selection techniques and their effects on ART outcome

ABSTRACT: Sperm selection in vitro has a direct impact on paternal contribution to preimplantation embryogenesis. Conventional sperm selection techniques are based on microscopic assessment of motility and morphology alone and do not include characteristics that influence the fertilization potential of spermatozoa. Chromosomal aberrations have been readily noted in sperms classified as normal via the Strict Kruger morphological assessment, questioning the value of using this parameter for sperm selection in intracytoplasmic sperm injection (ICSI) cycles. Furthermore, several studies have demonstrated that visual evaluation alone may inadvertently facilitate selection of sperms with compromised developmental, cytoplasmic, and nuclear competence. Hence, advanced techniques have been developed to address these issues in sperm selection. This review summarizes literature evidence on various advanced sperm selection techniques and their impact on assisted reproductive technology (ART) outcomes.
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NEWS: Selection of hyaluronan bound sperm may enhance ICSI outcomes

Sperm selection based on visual assessment alone has been speculated to be insufficient to identify sperm DNA integrity, which may play a major role in determining the outcome of intracytoplasmic sperm injection (ICSI) cycles. A recent, prospective, stratified, double-blinded, randomized controlled trial reports the benefits of utilizing the hyaluronan binding phenomenon for sperm selection in comparison to visual assessment alone in ICSI cycles. Researchers demonstrate that selection of hyaluronan-bound (HB) sperm in couples with a hylauronan-binding sperm proportion of ≤65% results in significant reduction in pregnancy loss rates.
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NEWS: Lycopene improves altered polyunsaturated fatty acid levels in seminal plasma of infertile males

An imbalance in the ratio of the polyunsaturated fatty acids (PUFAs), arachidonic acid and docosahexaenoic acid (AA/DHA) has been implicated in male infertility. A recent study highlights that treatment with lycopene significantly improves the AA/DHA ratio in the seminal plasma of infertile males and facilitates spontaneous as well as assisted conception among infertile couples. The study is claimed to be the first to report the efficacy of lycopene therapy in altering the AA/DHA ratio in seminal plasma and its ability to restore fertility in infertile couples.
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