NEWS: Inclusion of Letrozole in GnRH Antagonist Multiple Dose Protocol Improves IVF Outcomes in Poor Responders

Management of diminished ovarian reserve is challenging, despite the ongoing extensive research to develop an effective method of controlled ovarian stimulation (COS). Although various COS regimens such as GnRH agonist flare-up, GnRH agonist low dose long, and GnRH antagonist protocols have been developed, an efficient protocol for improving the outcomes in poor responders still remains elusive. A recent retrospective study highlights that letrozole cotreatment with GnRH antagonist multiple dose protocol (MDP) yields similar pregnancy outcomes with lesser dosage and shorter duration of rhFSH, compared to standard GnRH MDP protocol in IVF poor responders. The study results are published in Obstetrics and Gynecology Science.
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Posted in ART, Drugs, Female Infertility, IVF, IVF Outcome, Implantation, Infertility, News, PregnancyComments Off

Vitrified-warmed Blastocyst Transfers Found to have Similar Clinical Outcomes as Fresh Transfers

A vital component of any cryopreservation protocol used in ART is the minimal effect of the method on the preserved embryos. With its inherent benefits when compared to slow freezing, vitrification has been widely accepted worldwide and considering its widespread usage, numerous studies have evaluated the neonatal outcomes with encouraging results. Adding further credence to this technique, a recent retrospective study highlights that vitrified-warmed blastocyst transfers have equal live birth rates and enhanced neonatal outcomes in comparison to fresh transfers. The study findings are published in the journal, Fertility and Sterility.
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Posted in ART, Cryopreservation, Embryo Transfer, Embryology, Female Infertility, IVF, IVF Outcome, Infertility, PregnancyComments Off

Increased Oocyte Yield Observed with One-day Delay in Triggering Oocyte Maturation

Rise in the progesterone levels are known to negatively affect pregnancy rates; however, there is lack of sufficient evidence regarding their impact on oocyte yield. A recent randomized controlled trial reports that deferring oocyte maturation trigger by one day, in patients with low levels of progesterone, yielded higher number of mature oocytes. The study findings are published in Reproductive Biology and Endocrinology.
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Posted in ART, Endometrium, Female Infertility, IVF, IVF Outcome, Infertility, PregnancyComments Off

Subcutaneous and Vaginal Progesterone for LPS Found to be Equally Effective in Improving IVF Pregnancy Outcomes

Progesterone used for luteal phase support (LPS) is available commercially in different formulations, including oral capsules, intramuscular injection in oil, capsules for vaginal or rectal administration, and vaginal gel. Recently, water-soluble and subcutaneously injectable progesterone have been developed. To compare the efficacy and tolerability of the newly developed subcutaneous progesterone preparation with vaginal P gel for LPS, a first prospective, randomized, large, noninferiority, placebo-controlled study reported similar effectiveness and tolerability of both the preparations with respect to ART outcomes. The findings of the study have been published in the journal, Fertility and Sterility.
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NEWS: Study Highlights Association between Poor Response to Ovarian Stimulation and Higher Miscarriage Risk in IVF Cycles

Analyzing data from the Human Fertilization and Embryology Authority (HFEA) involving 124,351 IVF pregnancies, a UK study reported that the number of oocytes retrieved is strongly linked to clinical miscarriage rate. The study findings, which suggest the probable association between poor ovarian response and reduction in oocyte quantity and quality, are published in the latest edition of Human Reproduction.
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Posted in ART, Female Infertility, IVF, IVF Outcome, Infertility, Miscarriage, News, PregnancyComments Off

Influence of Economics on ART Access and Embryo Transfer Practices – Data from 30 High and Upper-middle Income Countries

Although it is well-known that the psycho-physical burden of the ART treatment is one of the most important factors that influence the withdrawal from the treatment, certain studies have also found that cost is a vital factor responsible for the decrease in ART access. A recent international study which analyzed the ART treatment, healthcare system, and socio-demographic data collected from 30 different upper and upper-middle income countries, further substantiated the impact of consumer cost on ART utilization and numbers of embryos transferred. The results of the study are published in the Fertility and Sterility journal.
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Retrospective Study Reports Embryo Quality and Progesterone Levels as Most Significant Predictors of Live Birth Rates in Fresh Embryo Transfer

A recent retrospective cohort study conducted on 2,525 infertile women has reaffirmed that embryo quality and progesterone levels on the day of hCG administration are important predictors of live birth rates and pregnancy, respectively, in fresh IVF cycles. The study findings are published in Journal of Assisted Reproduction and Genetics.

Qian Fang Cai from the Reproductive Medicine Center, Women and Children’s Hospital of Guangdong Province, China, and coworkers conducted the study to determine the independent predictors of live birth in fresh IVF cycles by assessing the effect of cohort-specific parameters such as the number of retrieved oocytes, antral follicle count (AFC), and number and quality of embryos. Bootstrap algorithm was used to identify independent predictors, and multivariable logistic regression was employed along with measurement of proportion of explained variation for comparing the value of transfer-specific and cohort-specific predictors.
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Posted in ART, Embryology, Female Infertility, IVF, IVF Outcome, Infertility, PregnancyComments Off

NEWS: Study Reiterates the Association of Sperm Viral Infection like HCMV with Male Infertility

Viral infection of testicular cells may alter testicular function, posing severe risk to fertility and potential transmission of virus-induced mutations to future generations. A review, published in Journal of Reproductive Immunology, highlighted the negative impact of sperm viral infections with human cytomegalovirus (HCMV), human papilloma virus (HPV), and herpes viruses (HSV) on male reproductive function. The researchers emphasized the importance of screening male infertility patients for viral infections like HCMV to avert transmission to partners and newborns and also to enhance natural or assisted conception outcomes.
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Posted in ART, Genetics, IVF, IVF Outcome, Male Infertility, NewsComments Off

Recent Study Highlights Adverse ART Outcomes associated with Overweight/Obese Women

Obesity adversely affects the reproductive health of a woman as it is known to cause anovulation, menstrual irregularities, and infertility. However, the findings of various studies on the influence of BMI on controlled ovarian hyperstimulation factors, such as quantity of gonadotropin and days of stimulation required, oocyte quality/ quantity, maximum level of estradiol, and success of pregnancy, are inconsistent. Reiterating the negative impact of high BMI on ART, a recent retrospective study, published in International Journal of Clinical and Experimental Medicine, noted the need for longer stimulation days and increased gonadotropin apart from lower pregnancy rates in such women during IVF/ICSI cycles.
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Posted in ART, Female Infertility, Fertility, ICSI, IVF, IVF Outcome, Infertility, PCOS, PregnancyComments Off

Literature Search Highlights Role of microRNAs associated with Endometrial Receptivity as Biomarkers in IVF

Endometrial receptivity plays a crucial role in embryo implantation and successful pregnancy; however, the key molecules or mechanisms associated with it are still unclear. A recent review, published in Current Drug Targets, highlighted the importance of better understanding the molecular mechanisms that affect endometrial receptivity and embryo implantation to improve the ART outcomes. Novel molecular targets such as microRNAs (miRNA) could serve as a biomarker for endometrial receptivity, thereby increasing the chances of implantation in both natural and artificial conception. Another recent study, published in Reproductive Sciences, identified the potential miRNA target genes that may be vital for endometrial receptivity like CAST, CFTR, FGFR2, and LIF. The findings emphasized the importance of miRNA and their target genes in endometrial receptivity.
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Posted in ART, Embryology, Genetics, IVF, IVF Outcome, InfertilityComments Off

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