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NEWS: Inclusion of Letrozole in GnRH Antagonist Multiple Dose Protocol Improves IVF Outcomes in Poor Responders

Management of diminished ovarian reserve is challenging, despite the ongoing extensive research to develop an effective method of controlled ovarian stimulation (COS). Although various COS regimens such as GnRH agonist flare-up, GnRH agonist low dose long, and GnRH antagonist protocols have been developed, an efficient protocol for improving the outcomes in poor responders still remains elusive. A recent retrospective study highlights that letrozole cotreatment with GnRH antagonist multiple dose protocol (MDP) yields similar pregnancy outcomes with lesser dosage and shorter duration of rhFSH, compared to standard GnRH MDP protocol in IVF poor responders. The study results are published in Obstetrics and Gynecology Science.
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Posted in ART, Drugs, Female Infertility, IVF, IVF Outcome, Implantation, Infertility, News, PregnancyComments Off

NEWS: Study Highlights Association between Poor Response to Ovarian Stimulation and Higher Miscarriage Risk in IVF Cycles

Analyzing data from the Human Fertilization and Embryology Authority (HFEA) involving 124,351 IVF pregnancies, a UK study reported that the number of oocytes retrieved is strongly linked to clinical miscarriage rate. The study findings, which suggest the probable association between poor ovarian response and reduction in oocyte quantity and quality, are published in the latest edition of Human Reproduction.
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Posted in ART, Female Infertility, IVF, IVF Outcome, Infertility, Miscarriage, News, PregnancyComments Off

NEWS: FertiQoL Tool Effective in Analyzing Quality Of Life in Infertile Couples

Analyzing the quality of life using FertiQoL, a recent study demonstrated that prolonged duration of infertility and the need for psychological support adversely affected the scores, while they were better in patients with higher educational status and secondary infertility. FertiQoL helps in identifying the impact of infertility on the wellbeing of couples, which would in turn enable healthcare providers to better address patient concerns and improve treatment outcomes. The study findings are published in European Journal of Gynecology and Reproductive Biology.
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Posted in ART, Female Infertility, Infertility, NewsComments Off

NEWS: Study Reiterates the Association of Sperm Viral Infection like HCMV with Male Infertility

Viral infection of testicular cells may alter testicular function, posing severe risk to fertility and potential transmission of virus-induced mutations to future generations. A review, published in Journal of Reproductive Immunology, highlighted the negative impact of sperm viral infections with human cytomegalovirus (HCMV), human papilloma virus (HPV), and herpes viruses (HSV) on male reproductive function. The researchers emphasized the importance of screening male infertility patients for viral infections like HCMV to avert transmission to partners and newborns and also to enhance natural or assisted conception outcomes.
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Posted in ART, Genetics, IVF, IVF Outcome, Male Infertility, NewsComments Off

NEWS: Effectiveness of Corifollitropin Alfa Found to be Similar to rFSH in COS Patients

In order to avoid the first seven of the daily injections of FSH and the hypersensitivity or immune reactions caused due to this repetitive treatment, a single injection of corifollitropin alfa has been suggested for patients undergoing controlled ovarian stimulation (COS). Several studies have compared its effectiveness with rFSH in terms of treatment outcomes with conflicting results. Now, a post hoc analysis of the ENGAGE trial reported that corifollitropin alfa and rFSH are similar with respect to ongoing pregnancy rates following ovarian stimulation in a gonadotropin-releasing hormone (GnRH) antagonist protocol.
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NEWS: IVF culture medium plays a crucial role in influencing intrauterine growth

It has been speculated that in vitro culture medium may significantly contribute to poor perinatal outcomes following assisted reproduction technology (ART) cycles. Now, a recent retrospective cohort study, published in the journal Human Reproduction, reports that the effect of the IVF culture medium on fetal development is obvious as early as the second trimester of gestation.
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NEWS: Cessation of GnRH antagonist on hCG trigger day may yield beneficial outcomes

The GnRH antagonist stimulation protocol has undergone several modifications over time in an attempt to improve the outcomes of controlled ovarian hyperstimulation (COH). A recent prospective randomized trial demonstrates that the total GnRH antagonist dose required in a flexible multiple-dose protocol can be reduced by withholding the antagonist on the day of hCG trigger, without affecting pregnancy rates.
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NEWS: Presence of soluble HLA-G in embryo culture medium serves as a valuable marker of pregnancy outcomes

Previous trials have demonstrated a positive association between secretion of soluble human leukocyte antigen G (sHLA-G) by embryos and a higher rate of pregnancy in in vitro fertilization (IVF) cycles. Now, a recent multicenter retrospective trial provides evidence to substantiate that sHLA-G is a useful noninvasive embryo marker to aid in improving pregnancy outcomes.
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NEWS: Carnitine supplementation may benefit women undergoing IVF therapy

Fatty acids play a crucial role in energy supply to oocytes and embryos, and L-carnitine mediates the β-oxidation of free fatty acids. A recent case-control study, published in the journal Reproductive Biology and Endocrinology, demonstrates the benefits of evaluation of carnitine profiles in women undergoing in vitro fertilization (IVF) therapy.
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NEWS: Benefits of in vitro treatment of spermatozoa with an antioxidant and micronutrient combination

Several studies have evaluated the beneficial effects of oral antioxidant administration on sperm physiology and fertility. However, data regarding the in vitro effects of antioxidants on spermatozoa is very sparse. Now, a recent study demonstrates the in vitro protective effect exerted by a combination of zinc (Zn), D-aspartate (D-Asp), and coenzyme Q10 (CoQ10) on sperm physiology parameters. Supplementation of culture medium with this antioxidant and micronutrient combination has been reported to prevent an increase in sperm DNA fragmentation and lipid peroxidation, and preclude a reduction in sperm motility.
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Posted in Infertility, Male Infertility, NewsComments Off

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