Archive | Fertility

NEWS: Inclusion of Letrozole in GnRH Antagonist Multiple Dose Protocol Improves IVF Outcomes in Poor Responders

Management of diminished ovarian reserve is challenging, despite the ongoing extensive research to develop an effective method of controlled ovarian stimulation (COS). Although various COS regimens such as GnRH agonist flare-up, GnRH agonist low dose long, and GnRH antagonist protocols have been developed, an efficient protocol for improving the outcomes in poor responders still remains elusive. A recent retrospective study highlights that letrozole cotreatment with GnRH antagonist multiple dose protocol (MDP) yields similar pregnancy outcomes with lesser dosage and shorter duration of rhFSH, compared to standard GnRH MDP protocol in IVF poor responders. The study results are published in Obstetrics and Gynecology Science.
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Posted in ART, Drugs, Female Infertility, IVF, IVF Outcome, Implantation, Infertility, News, PregnancyComments Off

Vitrified-warmed Blastocyst Transfers Found to have Similar Clinical Outcomes as Fresh Transfers

A vital component of any cryopreservation protocol used in ART is the minimal effect of the method on the preserved embryos. With its inherent benefits when compared to slow freezing, vitrification has been widely accepted worldwide and considering its widespread usage, numerous studies have evaluated the neonatal outcomes with encouraging results. Adding further credence to this technique, a recent retrospective study highlights that vitrified-warmed blastocyst transfers have equal live birth rates and enhanced neonatal outcomes in comparison to fresh transfers. The study findings are published in the journal, Fertility and Sterility.
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Posted in ART, Cryopreservation, Embryo Transfer, Embryology, Female Infertility, IVF, IVF Outcome, Infertility, PregnancyComments Off

Increased Oocyte Yield Observed with One-day Delay in Triggering Oocyte Maturation

Rise in the progesterone levels are known to negatively affect pregnancy rates; however, there is lack of sufficient evidence regarding their impact on oocyte yield. A recent randomized controlled trial reports that deferring oocyte maturation trigger by one day, in patients with low levels of progesterone, yielded higher number of mature oocytes. The study findings are published in Reproductive Biology and Endocrinology.
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Posted in ART, Endometrium, Female Infertility, IVF, IVF Outcome, Infertility, PregnancyComments Off

Subcutaneous and Vaginal Progesterone for LPS Found to be Equally Effective in Improving IVF Pregnancy Outcomes

Progesterone used for luteal phase support (LPS) is available commercially in different formulations, including oral capsules, intramuscular injection in oil, capsules for vaginal or rectal administration, and vaginal gel. Recently, water-soluble and subcutaneously injectable progesterone have been developed. To compare the efficacy and tolerability of the newly developed subcutaneous progesterone preparation with vaginal P gel for LPS, a first prospective, randomized, large, noninferiority, placebo-controlled study reported similar effectiveness and tolerability of both the preparations with respect to ART outcomes. The findings of the study have been published in the journal, Fertility and Sterility.
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Posted in ART, Female Infertility, IVF, IVF Outcome, Infertility, PregnancyComments Off

NEWS: Study Highlights Association between Poor Response to Ovarian Stimulation and Higher Miscarriage Risk in IVF Cycles

Analyzing data from the Human Fertilization and Embryology Authority (HFEA) involving 124,351 IVF pregnancies, a UK study reported that the number of oocytes retrieved is strongly linked to clinical miscarriage rate. The study findings, which suggest the probable association between poor ovarian response and reduction in oocyte quantity and quality, are published in the latest edition of Human Reproduction.
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Posted in ART, Female Infertility, IVF, IVF Outcome, Infertility, Miscarriage, News, PregnancyComments Off

Systematic Review and Meta-analysis Finds Little Evidence on Benefits of Cervical Mucus Removal Prior to Embryo Transfer in ART Cycles

Pregnancy rates during IVF/ICSI cycles may be adversely impacted even by small variations in embryo transfer methods. Although some studies have evaluated the impact of removal of cervical discharge on ART outcomes, there is a lack of consensus on the embryo transfer outcomes. A recent systematic review and meta-analysis, published in Fertility and Sterility, did not find any significant proof regarding the beneficial effects of cervical mucus removal before embryo transfer in improving the IVF/ICSI cycle outcomes.
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Posted in ART, Embryology, Female Infertility, ICSI, IVF Outcome, Infertility, PregnancyComments Off

New Prospective Cohort Study Reports the Association between Preconception Stress and Enhanced Infertility Risk

Literature evidence suggests a close inter-relationship between stress and reproduction, but its directionality is not clearly known. Recently, a US study demonstrated that increased stress levels in couples, as evaluated by salivary alpha-amylase, may lead to longer time-to-pregnancy (TTP) and a higher risk of infertility. The findings, touted to be the first in the world to prospectively link salivary stress markers with infertility, are published in the journal Human Reproduction.
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Posted in Female Infertility, Fertility, Infertility, Male Infertility, PregnancyComments Off

NEWS: New Study Demonstrates that Ovarian Endometriomas Do Not Affect Ooctye Quality in IVF Cycles

Literature search reveals contradictory findings on the effect of ovarian endometriomas on IVF outcomes. Now, a recent prospective study, published in Fertility and Sterility, provides further insight and hope to patients with ovarian endometriomas by indicating the absence of any detrimental effect on oocyte developmental competence.
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Posted in ART, Female Infertility, IVF Outcome, Infertility, Pregnancy, SurgeryComments Off

NEWS: Deselection of Physiologically Abnormal Spermatozoa Before ICSI Reduces Birth Defects and Improves Clinical Results

Sperm morphology plays a vital role in determining fertility and is associated with fertilization and pregnancy rates in spontaneous as well as induced pregnancy. Highlighting the importance of the selection of morphologically normal spermatozoa for ART treatment, a recent prospective population-based study demonstrated that major birth defects were significantly higher in standard ICSI than intracytoplasmic injection of morphologically selected spermatozoa (IMSI). The study findings, published in Reproductive BioMedicine Online, further reiterated the need for long term follow up and research to estimate the prevalence and risk of specific IMSI-based birth defects.
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Posted in ART, Genetics, ICSI, IVF Outcome, Infertility, Male Infertility, Pregnancy, TechnologyComments Off

Retrospective Study Reports Embryo Quality and Progesterone Levels as Most Significant Predictors of Live Birth Rates in Fresh Embryo Transfer

A recent retrospective cohort study conducted on 2,525 infertile women has reaffirmed that embryo quality and progesterone levels on the day of hCG administration are important predictors of live birth rates and pregnancy, respectively, in fresh IVF cycles. The study findings are published in Journal of Assisted Reproduction and Genetics.

Qian Fang Cai from the Reproductive Medicine Center, Women and Children’s Hospital of Guangdong Province, China, and coworkers conducted the study to determine the independent predictors of live birth in fresh IVF cycles by assessing the effect of cohort-specific parameters such as the number of retrieved oocytes, antral follicle count (AFC), and number and quality of embryos. Bootstrap algorithm was used to identify independent predictors, and multivariable logistic regression was employed along with measurement of proportion of explained variation for comparing the value of transfer-specific and cohort-specific predictors.
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Posted in ART, Embryology, Female Infertility, IVF, IVF Outcome, Infertility, PregnancyComments Off

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