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Intravenous Calcium Infusion Effective in Preventing OHSS in High-risk Patients

The pathogenesis of ovarian hyperstimulation syndrome (OHSS), although not completely elucidated, is associated with the increased vascular endothelial growth factor (VEGF)-mediated blood vessel permeability. A recent hypothesis on OHSS pathophysiology proposed the involvement of intra- and extracellular calcium ions in the onset and development of OHSS. This was independent of, but not contradictory to, the vascular permeability mechanism. Now, a recent study, published in Journal of Human Reproductive Sciences, demonstrated the effectiveness of calcium infusion in reducing the occurrence rates of OHSS and also preventing severe OHSS in high-risk patients such as those with polycystic ovary syndrome (PCOS). The results reported comparable potential of intravenous calcium gluconate infusion with VEGF antagonist, cabergoline.
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Posted in ART, IVF Outcome, Infertility, OHSS, PCOS, PregnancyComments Off



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