Archive | ICSI

New Study Reassures on the Use of Assisted Oocyte Activation in ICSI Cycles

A recent study reports that the behavioral and neurodevelopment outcomes are normal in children born after assisted oocyte activation (AOA) using calcium ionophore in ICSI cycles. Touted to be the first study assessing the developmental outcome of children born following AOA, the preliminary findings are published in Reproductive BioMedicine Online.
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Systematic Review and Meta-analysis Finds Little Evidence on Benefits of Cervical Mucus Removal Prior to Embryo Transfer in ART Cycles

Pregnancy rates during IVF/ICSI cycles may be adversely impacted even by small variations in embryo transfer methods. Although some studies have evaluated the impact of removal of cervical discharge on ART outcomes, there is a lack of consensus on the embryo transfer outcomes. A recent systematic review and meta-analysis, published in Fertility and Sterility, did not find any significant proof regarding the beneficial effects of cervical mucus removal before embryo transfer in improving the IVF/ICSI cycle outcomes.
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Posted in ART, Embryology, Female Infertility, ICSI, IVF Outcome, Infertility, PregnancyComments Off

NEWS: Deselection of Physiologically Abnormal Spermatozoa Before ICSI Reduces Birth Defects and Improves Clinical Results

Sperm morphology plays a vital role in determining fertility and is associated with fertilization and pregnancy rates in spontaneous as well as induced pregnancy. Highlighting the importance of the selection of morphologically normal spermatozoa for ART treatment, a recent prospective population-based study demonstrated that major birth defects were significantly higher in standard ICSI than intracytoplasmic injection of morphologically selected spermatozoa (IMSI). The study findings, published in Reproductive BioMedicine Online, further reiterated the need for long term follow up and research to estimate the prevalence and risk of specific IMSI-based birth defects.
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Recent Study Highlights Adverse ART Outcomes associated with Overweight/Obese Women

Obesity adversely affects the reproductive health of a woman as it is known to cause anovulation, menstrual irregularities, and infertility. However, the findings of various studies on the influence of BMI on controlled ovarian hyperstimulation factors, such as quantity of gonadotropin and days of stimulation required, oocyte quality/ quantity, maximum level of estradiol, and success of pregnancy, are inconsistent. Reiterating the negative impact of high BMI on ART, a recent retrospective study, published in International Journal of Clinical and Experimental Medicine, noted the need for longer stimulation days and increased gonadotropin apart from lower pregnancy rates in such women during IVF/ICSI cycles.
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Posted in ART, Female Infertility, Fertility, ICSI, IVF, IVF Outcome, Infertility, PCOS, PregnancyComments Off

New Study reports Effectiveness of Varicocelectomy in Improving ICSI outcomes

Studies have shown inconsistent results regarding the effect of varicocelectomy on fertility and ART outcome. A recent retrospective study, published in International Urology and Nephrology, reported the beneficial effects of varicocelectomy in improving pregnancy and live birth rates in infertile couples, wherein the male partner has clinical varicocele.
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NEWS: Singleton pregnancies following IVF associated with adverse perinatal outcomes

A higher prevalence of preterm births and small-for-gestational age children compared to normal pregnancies has been reported in IVF-assisted singleton pregnancies. Now, a recent study has confirmed that IVF pregnancies in contrast to spontaneous pregnancies have suboptimal perinatal outcomes.
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NEWS: Use of combined stimulation protocol may represent a breakthrough in IVF practice

Use of an optimal ovarian stimulation protocol is a crucial factor influencing the success of in vitro fertilization (IVF) therapy. A recent study, published in the European Review for Medical and Pharmacological Sciences, demonstrates that employing a combined stimulation protocol comprising of human FSH (hFSH) followed by recombinant FSH (rFSH) may positively influence assisted reproductive technology (ART) outcomes.
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NEWS: Vitrification has no adverse effect on oocyte viability

Cryopreservation of oocytes has made rapid strides in recent years, and the new freezing technique of vitrification has led to better oocyte survival rates. Intracytoplasmic sperm injection of cryopreserved oocytes has demonstrated a fertilization rate of 70-90% and a pregnancy rate of 10-40%. Now, a recent prospective study has confirmed that vitrification does not have any harmful effect on oocyte viability.
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NEWS: Children conceived after IVF at mild risk of mental retardation

Ever since the birth of the first child conceived through in vitro fertilization (IVF) in 1978, the field of assisted reproductive technology (ART) has witnessed significant improvements and has benefited innumerable couples with infertility disorders. However, concerns have been raised that ART conceived children might be exposed to greater health risks when compared to children conceived naturally. A recent population-based, prospective cohort study reports that children born after IVF have a mild, but statistically significant elevated risk for mental retardation, when compared to those conceived naturally.
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NEWS: Normal responders rather than high responders benefit from elective single blastocyst transfer

The field of assisted reproductive technology (ART) has witnessed significant improvements over the past few decades. Despite advancements, there is a substantial risk of obstetric and neonatal complications following multiple embryo transfer. The optimal number of embryos to be transferred while still maintaining adequate pregnancy rates remains a challenge in ART cycles. A recent retrospective study reports that multiple pregnancy rates can be reduced and satisfactory pregnancy rates achieved using elective single blastocyst transfer (eSBT) and frozen-thawed embryo transfer (FET) in normal and high responders, respectively.
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