Archive | Implantation

NEWS: Inclusion of Letrozole in GnRH Antagonist Multiple Dose Protocol Improves IVF Outcomes in Poor Responders

Management of diminished ovarian reserve is challenging, despite the ongoing extensive research to develop an effective method of controlled ovarian stimulation (COS). Although various COS regimens such as GnRH agonist flare-up, GnRH agonist low dose long, and GnRH antagonist protocols have been developed, an efficient protocol for improving the outcomes in poor responders still remains elusive. A recent retrospective study highlights that letrozole cotreatment with GnRH antagonist multiple dose protocol (MDP) yields similar pregnancy outcomes with lesser dosage and shorter duration of rhFSH, compared to standard GnRH MDP protocol in IVF poor responders. The study results are published in Obstetrics and Gynecology Science.
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Posted in ART, Drugs, Female Infertility, IVF, IVF Outcome, Implantation, Infertility, News, PregnancyComments Off

NEWS: Uterine length affects fertility outcomes in IVF therapy

Embryo transfer, despite being the final critical step in IVF therapy, has till recently not received due attention from researchers. Previous studies have reported that knowledge of the position and size of the uterus during embryo transfer may aid in improving pregnancy outcomes. Now, a recent retrospective cohort study, published in the journal Human Reproduction, has shown an association between uterine length and IVF outcomes.
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NEWS: Low-molecular-weight heparin may improve ART outcomes in women with recurrent implantation failure

Numerous adjuncts have been tested to improve pregnancy rates in women with recurrent implantation failure (RIF) in assisted reproductive technology (ART) cycles. A recent study, published in the journal Human Reproduction Update, reports that adjunct use of low molecular weight heparin (LMWH) significantly improves live birth rates in women with ≥3 RIF.
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NEWS: Bed rest following embryo transfer speculated to adversely impact IVF outcomes

Embryo implantation in in vitro fertilization (IVF) therapy is a complicated process influenced by several factors such as endometrial receptivity and embryo quality. Numerous interventions have been tested towards improving implantation, and although implantation failure is not usually associated with increased activity, bed rest is commonly prescribed. However, a recent study has proved that bed rest following embryo transfer (ET) may have a negative influence on IVF outcomes.
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Posted in ART, Embryo Transfer, Embryology, IVF, IVF Outcome, ImplantationComments Off

NEWS: Time-lapse imaging and morphokinetic analysis help identify embryo risk for aneuploid chromosomes

Time-lapse imaging of preimplantation embryos is increasingly being employed in assisted reproduction treatment. This technique has facilitated the use of objective algorithms based on embryo morphokinetic variables for embryo selection. A recent study has detailed the use of time-lapse imaging using defined morphokinetic data for detecting embryos at risk of having aneuploid chromosome structure, without the need to perform preimplantation genetic screening.
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Posted in ART, Embryology, ICSI, IVF, IVF Outcome, ImplantationComments Off

NEWS: Conversion of high-response gonadotropin IUI cycles to rescue IVF cycles yields better outcomes than regular IVF

Intrauterine insemination (IUI) is usually the first line of treatment in unexplained and mild male factor subfertility. Although IUI may improve pregnancy rates, supernumerary follicles in high responding women increase their risk for multiple pregnancy and ovarian hyperstimulation syndrome (OHSS), particularly in gonadotropin cycles. A recent study reports the benefits of conversion of high-response gonadotropin IUI cycles to rescue IVF cycles when compared with hyper-responder IVF controls.
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Posted in ART, Embryology, IVF, IVF Outcome, ImplantationComments Off

NEWS: Preliminary evidence indicates high anti-PLAC1 antibody level may serve as a biomarker of repeated IVF implantation failure

Previous studies indicate that autoimmune antibodies may have an impact on implantation failure in in vitro fertilization-embryo transfer (IVF-ET) cycles. A recent observational, case-controlled clinical trial highlights that high circulating anti-placenta-specific 1 (PLAC1) antibody levels could be associated with an increased likelihood of repeated IVF-ET implantation failure.
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Posted in Female Infertility, IVF Outcome, Implantation, NewsComments Off

NEWS: Expression of fibroblast growth factor-1 may likely influence implantation

Recurrent implantation failure post in vitro fertilization (IVF) therapy has been attributed to numerous maternal and embryonic factors. A recent study, published in the European Review for Medical and Pharmacological Sciences, indicates that fibroblast growth factor-1 (FGF-1) may play a crucial role as a maternal factor influencing implantation.
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NEWS: Depth of embryo transfer into the uterine cavity reported to influence IVF treatment outcomes

Various factors influence the success of in vitro fertilization and embryo transfer (IVF-ET) cycles. A recent prospective observational study indicates that the depth of embryo transfer into the uterine cavity should be regarded as a vital factor that affects treatment success.
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NEWS: Single endometrial biopsy regimen before ICSI cycles to benefit patients with repeated implantation failure

Reduced endometrial receptivity has been implicated as one of the causes for repeated implantation failures in assisted reproduction technology (ART) cycles. Previous studies have indicated that the chances of implantation can be improved by an intentional endometrial injury, either in the form of a curettage or biopsy, before embryo transfer. A recent prospective randomized controlled trial, published in the European Journal of Obstetrics & Gynecology, and Reproductive Biology, further substantiates that a single endometrial biopsy regimen (S-EBR) performed during hysteroscopy significantly increases the rates of implantation, clinical pregnancy, and live birth when compared to hysteroscopy, sans endometrial scraping. Continue Reading

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