Archive | Drugs

NEWS: Inclusion of Letrozole in GnRH Antagonist Multiple Dose Protocol Improves IVF Outcomes in Poor Responders

Management of diminished ovarian reserve is challenging, despite the ongoing extensive research to develop an effective method of controlled ovarian stimulation (COS). Although various COS regimens such as GnRH agonist flare-up, GnRH agonist low dose long, and GnRH antagonist protocols have been developed, an efficient protocol for improving the outcomes in poor responders still remains elusive. A recent retrospective study highlights that letrozole cotreatment with GnRH antagonist multiple dose protocol (MDP) yields similar pregnancy outcomes with lesser dosage and shorter duration of rhFSH, compared to standard GnRH MDP protocol in IVF poor responders. The study results are published in Obstetrics and Gynecology Science.
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Posted in ART, Drugs, Female Infertility, IVF, IVF Outcome, Implantation, Infertility, News, PregnancyComments Off

Modalities to relieve pain during oocyte retrieval: A brief review

Abstract: Ultrasound-guided transvaginal oocyte retrieval has replaced the earlier more invasive laparoscopic approach. Despite being a short procedure lasting for about 10 to 15 minutes, it is associated with significant pain. Management of pain during oocyte retrieval is vital to ensure patient comfort and treatment success since majority of the couples undergoing in vitro fertilization are already under great stress. Furthermore, psychological well being has been reported to impact implantation rates. Various methods have been suggested to alleviate pain and increase the chances of successful oocyte retrieval. This is a brief review of the different modalities used to relieve pain during oocyte retrieval.
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NEWS: Risk of borderline ovarian tumor reported to be increased in women undergoing IVF therapy

Several investigators have raised concerns regarding the potential association between the use of fertility drugs and ovarian cancer risk. A recent population cohort study has reported that in vitro fertilization (IVF) therapy increases a woman’s risk of developing borderline ovarian tumors.

Louise Stewart and coworkers from the School of Population Health, The University of Western Australia, evaluated the risk of borderline ovarian tumors in women undergoing IVF when compared with their infertile counterparts not undergoing IVF. The participants were aged 20-44 years. The effect of IVF therapy and potential confounding factors (age, parity, calendar year, infertility due to pelvic inflammatory disorders or endometriosis, socio-economic status, hysterectomy, tubal ligation) on the rate of borderline ovarian tumors was examined using Cox regression analysis.
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Dutch Study reports Increased Malignancy Risk with Long-term Ovarian Stimulation

With the increasing use of fertility drugs over the past few decades, there is growing concern of their potential carcinogenic effect. Now, a large Dutch cohort study has published new evidence supporting enhanced risk of ovarian tumors, especially borderline ovarian cancer, with the use of ovarian stimulation drugs during IVF cycles.

Cryopreservation is Useful for Preserving Fertility in Hodgkin Lymphoma Patients

It has been observed that long-term survivors of lifesaving cancer therapies are at great risk of gonadal toxicity. Now, a study reviewing the impact of Hodgkin lymphoma therapy on male and female fertility, reiterates the usefulness and effectiveness of cryopreservation for fertility preservation in such patients. Continue Reading

Posted in ART, Cryopreservation, Drugs, Embryology, Female Infertility, Fertility, Fertility Preservation, IVF, IVF Outcome, Infertility, Male InfertilityComments Off

Elevated FSH levels in Male Childhood Cancer Survivors May Predict Need for Future ART

Pediatric oncologists have noted a significant increase in the number of childhood cancer survivors as a result of advancements in the medical field, which has raised the concerns of post-cancer reproductive health. Highlighting the presence of elevated FSH levels in one-third of young adult male childhood cancer survivors evaluated, a recent study has found FSH to be an extremely sensitive marker for cancer survivors who may require ART subsequently. Continue Reading

Posted in ART, Drugs, Endocrinology, Fertility, Fertility Preservation, Infertility, Male InfertilityComments Off

FSH Administration during hCG Trigger may Improve Oocyte Developmental Competence in IVF Cycles

The increase in the success rates of ART over the past few decades has been mainly attributed to improved laboratory conditions and ovarian stimulation optimization, with less attention directed towards strategies for enhancing final oocyte maturation. A recent study, touted to be the first randomized double blind placebo-controlled clinical trial to alter the ovulation trigger to enhance the developmental competence of oocytes in IVF cycles, has reported a statistically significant improvement in fertilization after a follicle stimulating hormone (FSH) bolus administration at the time of human chorionic gonadotropin (hCG) trigger, compared to placebo, in IVF cycles. Continue Reading

Posted in ART, Drugs, Endocrinology, Female Infertility, Fertility, Fertility Preservation, Guidelines, ICSI, IVF, IVF Outcome, Infertility, Laboratory, Pregnancy, TechnologyComments Off

Meta-analysis Reports Better IUI Pregnancy Rates with Recombinant FSH Compared to Same Dose of Highly Purified Urinary FSH

The in vitro production of pure FSH using recombinant DNA technology (rFSH) with high batch-to-batch consistency has led to it being considered as a better alternative to urinary FSH. A new systemic review and meta-analysis reports that use of rFSH is associated with an increased pregnancy rate (PR) per IUI cycle compared to the same dose of highly purified urinary FSH (HP-FSH). Interestingly, the PRs were comparable on using 50% reduced dose of rFSH. Continue Reading

Posted in ART, Drugs, Endocrinology, Female Infertility, Fertility, IUI, IVF, IVF Outcome, Infertility, Male Infertility, Media and Consumables, Technology0 Comments

NEWS: Study Reports Efficacy of Pentoxifylline in Identifying Viable Spermatozoa in Biopsy Samples

Earlier studies have suggested different methods, such as hypo-osmotic swelling (HOS) test, mechanical touch and laser touch techniques, and pentoxifylline (PF) addition, for the selection of viable sperms from testicular biopsy samples, in order to improve ART outcomes. A recent open, comparative, prospective study has reiterated that selecting viable sperms using the PF method is superior to the HOS test with regard to fertilization and pregnancy rates. The findings were published in the recent issue of the journal, Fertility and Sterility. Continue Reading

Posted in ART, Drugs, Fertility, ICSI, IUI, IVF, IVF Outcome, Infertility, Laboratory, Male Infertility, Pregnancy, TechnologyComments Off

NEWS: Polyanionic Microbicide for Sperm Washing Shown to Reduce HIV Transmission during ART

NEWS: Polyanionic Microbicide for Sperm Washing Shown to Reduce HIV Transmission during ART

Sperm washing alone may aid in reducing the risk of transmitting HIV infection to the partner and offspring; however, several studies have noted that HIV titers could still be significant in around 4-6% of washed sperm samples. A team of US researchers have reported the potential of an improved sperm washing method, which includes the use of a microbicide, polyanionic microbicide (PPCM), and extracellular Ca2+ in the washing media, in significantly lowering the HIV infectivity compared to traditional washing techniques. The study findings are published in the journal, ISRN Obstetrics and Gynecology. Continue Reading

Posted in ART, Drugs, Featured, ICSI, IUI, Infertility, Laboratory, Male Infertility, Media and Consumables, News, Pregnancy, TechnologyComments Off


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