Archive | Endocrinology

NEWS: Oral contraceptives with high androgenic progestins reported to suppress oocyte yields

A recent retrospective study demonstrates that use of oral contraceptives with high androgenic progestin suppresses functional ovarian reserve and oocyte yields in young oocyte donors. Accordingly, researchers highlight the need for reevaluating the routine practice of using oral contraceptives prior to in vitro fertilization (IVF) cycles.
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Posted in Donors, Endocrinology, Female Infertility, IVF, NewsComments Off

NEWS: Recombinant FSH therapy may improve sperm DNA integrity in oligoasthenoteratozoospermic men

Men with oligoasthenoteratozoospermia present with greater sperm DNA fragmentation (DFI) than those with normozoospermia. Considered the first to report the advantages of recombinant human FSH (rhFSH) administration on sperm DNA integrity, a recent prospective randomized controlled study suggests that rhFSH treatment for 3 months reduces DFI values, thereby improving sperm DNA integrity in men with idiopathic oligoasthenoteratozoospermia (iOAT). Continue Reading

Posted in ART, Endocrinology, Fertility, ICSI, IVF, Infertility, Male Infertility, NewsComments Off

Study Reports Increased Depression and Anxiety after Nonobstructive Azoospermia Diagnosis

The psychological outcome of infertility on women has been extensively studied in the past; however, research on the effect of the diagnosis of azoospermia on men and their fertile spouses is lacking. Now, a recent study, touted to be the first to report the negative effect of infertility on the physical and psychological wellness of men and their fertile female partners, has reported a definite association. Continue Reading

Posted in Endocrinology, Fertility, IVF, IVF Outcome, Infertility, Male InfertilityComments Off

Elevated FSH levels in Male Childhood Cancer Survivors May Predict Need for Future ART

Pediatric oncologists have noted a significant increase in the number of childhood cancer survivors as a result of advancements in the medical field, which has raised the concerns of post-cancer reproductive health. Highlighting the presence of elevated FSH levels in one-third of young adult male childhood cancer survivors evaluated, a recent study has found FSH to be an extremely sensitive marker for cancer survivors who may require ART subsequently. Continue Reading

Posted in ART, Drugs, Endocrinology, Fertility, Fertility Preservation, Infertility, Male InfertilityComments Off

Metformin Before and During ART Effective in Non-obese PCOS Women

Metformin is frequently used to help induce ovulatory menstrual cycles in polycystic ovary syndrome (PCOS) patients with oligomenorrhea. A recent multicenter, prospective, randomized, double-blind study reports that 12 weeks of metformin treatment prior to and during IVF/ICSI cycles, as opposed to placebo, substantially increases pregnancy and live birth rates in non-obese PCOS patients. Continue Reading

Posted in ART, Endocrinology, Female Infertility, Fertility, ICSI, IVF, IVF Outcome, Infertility, PCOS, PregnancyComments Off

FSH Administration during hCG Trigger may Improve Oocyte Developmental Competence in IVF Cycles

The increase in the success rates of ART over the past few decades has been mainly attributed to improved laboratory conditions and ovarian stimulation optimization, with less attention directed towards strategies for enhancing final oocyte maturation. A recent study, touted to be the first randomized double blind placebo-controlled clinical trial to alter the ovulation trigger to enhance the developmental competence of oocytes in IVF cycles, has reported a statistically significant improvement in fertilization after a follicle stimulating hormone (FSH) bolus administration at the time of human chorionic gonadotropin (hCG) trigger, compared to placebo, in IVF cycles. Continue Reading

Posted in ART, Drugs, Endocrinology, Female Infertility, Fertility, Fertility Preservation, Guidelines, ICSI, IVF, IVF Outcome, Infertility, Laboratory, Pregnancy, TechnologyComments Off

Meta-analysis Reports Better IUI Pregnancy Rates with Recombinant FSH Compared to Same Dose of Highly Purified Urinary FSH

The in vitro production of pure FSH using recombinant DNA technology (rFSH) with high batch-to-batch consistency has led to it being considered as a better alternative to urinary FSH. A new systemic review and meta-analysis reports that use of rFSH is associated with an increased pregnancy rate (PR) per IUI cycle compared to the same dose of highly purified urinary FSH (HP-FSH). Interestingly, the PRs were comparable on using 50% reduced dose of rFSH. Continue Reading

Posted in ART, Drugs, Endocrinology, Female Infertility, Fertility, IUI, IVF, IVF Outcome, Infertility, Male Infertility, Media and Consumables, Technology0 Comments

First Evidence on Role of the Skeletal System as an Endocrine Regulator of Male Fertility

First Evidence on Role of the Skeletal System as an Endocrine Regulator of Male Fertility

The physiological association between the reproductive and skeletal systems was thought to be restricted only to gonad-mediated regulation of bone remodeling until recently. A new animal study published in the journal, Cell has provided first evidence about the likely regulatory role of osteoblast-derived osteocalcin on male fertility. The findings may aid in gaining further insight into functions of the skeletal system that were hitherto not clearly understood. It would also help determine whether long-term use of drugs that affect the skeletal system by altering osteocalcin levels could, in turn, affect male fertility. Continue Reading

Posted in Endocrinology, Featured, Fertility, Infertility, Male Infertility, NewsComments Off

Study Validates Association of Endometrial Thickness with ART Success

Endometrial thickness, an indirect indicator for endometrial receptivity, has been used as a marker for assessing the receptivity of the endometrium and pregnancy rates in ART cycles. A new retrospective study published in the journal, La Tunisie Medicale has suggested that endometrial thickness greater than 12 mm may enhance IVF outcomes, and reported the correlation of endometrial thickness with statistically significant success rates of ICSI cycles. Continue Reading

Posted in ART, Endocrinology, Endometrium, Fertility, ICSI, IVF, IVF Outcome, PregnancyComments Off

Study Reports Potential of Anti-ovarian Antibody Testing in Infertility Management

Several trials have suggested a correlation between high concentrations of anti-ovarian antibodies (AOA) in women with low estradiol response to gonadotropin hormone stimulation, reduced pregnancy rate, and repeated IVF failure. A new study, reiterating this correlation, has suggested that including AOA evaluation in the array of tests used for diagnosing and treating infertility may be useful. The study findings are published in the Journal of Assisted Reproduction and Genetics. Continue Reading

Posted in Diagnostics, Endocrinology, Female Infertility, Fertility, Fertility Preservation, Implantation, Infertility, Laboratory, Pregnancy, TechnologyComments Off


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