Tag Archive | "genetic defect"

Researchers Identify Molecular Defect that Prevents Oocyte Activation


Several previous studies have tried to elucidate the complex signaling phenomenon underlying the mammalian oocytes activation. Intracellular Ca2+ oscillations triggered by the penetrated spermatozoa have been found to be crucial for both oocyte activation as well as normal embryo development. Now, a collaborative study conducted by US and UK researchers has reported that the abnormal expression of phospholipase Czeta 1 (PLCZ1) sperm protein is linked to the inability of the human sperm to induce Ca2+ oscillations, leading to failure of egg activation and sterility. Read the full story

Posted in ART, Embryology, Genetics, ICSI, IVF, Infertility, Male InfertilityComments (0)



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